www.alysivut.fi


Antroposofinen lääketiede:
vaikuttavuus, käyttö, kustannukset, turvallisuus

lue lisää


Tietoja antroposofisesta lääketieteestä

Download pdf


Facts and Figures Anthroposophic Medicine

Download pdf


Antroposofinen lääketiede EU:ssa

CAMbrella: www.cambrella.eu

CAMDOC/EUROCAM
www.camdoc.eu


Sivukartta

Onkologia ja mistelihoito: Kirjallisuus ja tutkimustuloksia

(Päivitetty 6.2.2019)

(Katso myös www.mistel-therapie.de)

Mistelihoito: Tuoremmat tutkimustulokset

Integrative cancer care in a certified Cancer Centre of a German Anthroposophic hospital. Thronickea A, Li Oeia S, Merklea A Herbstreit C, Lemmens H-P, Grah C, Kröz M, Matthes H, Schad F. Complementary Therapies in Medicine, Volume 40, October 2018, Pages 145-150 https://doi.org/10.1016/j.ctim.2018.03.012 Open access

A 4-year non-randomized comparative phase–IV study of early rheumatoid arthritis: integrative anthroposophic medicine for patients with preference against DMARDs versus conventional therapy including DMARDs for patients without preference. Hamre H J, Pham Van N, Kern Ch, Rau R, Klasen J, Schendel U, Gerlach L, Drabik A, Simon L; Patient Preference and Adherence 2018 12: 375-97 DOI: https://doi.org/10.2147/PPA.S145221

Integrative cancer care in a certified Cancer Centre of a German Anthroposophic hospital. Thronicke A, Li Oei S, Merkle A, Herbstreit C, Lemmens HP, Grah C, Kröz M, Matthes H, Schad F; Complementary Therapies in Medicine 2018 DOI: https://doi.org/10.1159/000478655

Durable Clinical Remission of a Skull Metastasis Under Intralesional Viscum album Extract Therapy - A Case Report. Werthmann PG, Huber R, Kienle GS. Head & Neck 2018;00:1–5. Read more

A 21-year course of Merkel cell carcinoma with adjuvant Viscum album extract treatment: A case report. Werthmann PG, Kindermann L, Kienle GS. Complementary Therapies in Medicine. Volume 38, June 2018, Pages 58-60. Read more

Overall survival of stage IV non-small cell lung cancer patients treated with Viscum album L. in addition to chemotherapy, a real-world observational multicenter analysis. Schad F, Thronick e A, Steele ML, Merkle A, Matthes B, Grah C, et al. (2018). PLoS ONE 13(8): e0203058. Open access

Clinical Safety of Combined Targeted and Viscum album L. Therapy in Oncological Patients. Thronicke A, Li Oei S, Merkle A, Matthes H, Schad, F (2018) Medicines 2018, 5, 100; doi:10.3390/medicines5030100. Open access

Complete Remission and Long-term Survival of a Patient with a Diffuse Large B-cell Lymphoma Under Viscum album Extracts After Resistance to R-CHOP: A Case Report. Gutsch J, Werthmann PG, Rosenwald A, Kienle GS: Anticancer Research. September 2018 vol. 38 no. 9 5363-5369. doi: 10.21873/anticanres.12865 Open access

Long-term tumor-free survival in a metastatic pancreatic carcinoma patient with FOLFIRINOX/Mitomycin, high-dose, fever inducing Viscum album extracts and subsequent R0 resection: A case report. Werthmann PG, Inter P, Welsch T, Sturm A-K, Grützmann R, Debus M u. a. . Medicine. Dezember 2018;97(49):e13243. Full text

Intralesional and subcutaneous application of Viscum album L. (European mistletoe) extract in cervical carcinoma in situ. A CARE compliant case report.Reynel MB, Villegas Y, Kiene H, Werthmann PG, Kienle GS: Medicine: November 2018 - Volume 97 - Issue 48 - p e13420, doi: 10.1097/MD.0000000000013420. Full text

Integrative cancer care in a certified Cancer Centre of a German Anthroposophic hospital. Thronickea A, Li Oeia S, Merklea A Herbstreit C, Lemmens H-P, Grah C, Kröz M, Matthes H, Schad F. Complementary Therapies in Medicine, Volume 40, October 2018, Pages 145-150 https://doi.org/10.1016/j.ctim.2018.03.012 Open access

Clinical safety of combined therapy of immune checkpoint inhibitors and Viscum album L. therapy in patients with advanced or metastatic cancer. Thronicke A, Steele ML, Grah C, Matthes B, Schad F (2017). BMC Complementary and Alternative Medicine 17:534. 10 pp. DOI: 10.1186/s12906-017-2045-0

Immune-related and adverse drug reactions to low versus high initial doses of Viscum album L. in cancer patients. Schad F, Thronicke A, Merkle A, Matthes H, Steele ML (2017). Phytomedicine 36, 54-58. DOI: 10.2016/j.phymed.2017.09.004

Safety of intravenously applied mistletoe extract – results from a phase I dose escalation study in patients with advanced cancer. Huber R, Schlodder D, Effertz C, Rieger S, Tröger W (2017). BMC Complementary and Alternative Medicine 17:465. 8 pp. DOI: 10.1185/s12906-017-1971-1

Effects of mistletoe products on pharmacokinetic drug turnover by inhibition and induction of cytochrome P450 activities. Schink M, Dehus O (2017). BMC Complemetary and Alternative Medicine 17:521. 8 pp. DOI: 10.1186/s12096-017-2028-1

Impact of a combined multimodal-aerobic and multimodal intervention compared to standard aerobic treatment in breast cancer survivors with chronic cancerrelated fatigue - results of a three-armed pragmatic trial in a comprehensive cohort design. Kröz M, Reif M, Glinz A, Berger B, Nikolaou A, Zerm R, Brinkhaus B, Girke M, Büssing A, Gutenbrunner C, and On behalf of the CRF-2 study group. BMC Cancer (2017) 17:166. DOI 10.1186/s12885-017-3142-7. Full article Open Access: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5335840/

Viscum album neutralizes tumor-induced immunosuppression in a human in vitro cell model. Steinborn C, Klemd AM, Sanchez- Campillo A-S, Rieger S, Scheffen M, Sauer B, et al. (2017) PLoS ONE 12(7): e0181553. https://doi. org/10.1371/journal.pone.0181553

Mistelihoito: katsaukset

Integrative Therapies During and After Breast Cancer Treatment: ASCO Endorsement of the SIO Clinical Practice Guideline. Gary H. Lyman, Heather Greenlee, Kari Bohlke, Ting Bao, Angela M. DeMichele, Gary E. Deng, Judith M. Fouladbakhsh, Brigitte Gil, Dawn L. Hershman, Sami Mansfield, Dawn M. Mussallem, Karen M. Mustian, Erin Price, Susan Rafte, and Lorenzo Cohen. J Clin Oncol 36:2647-2655. © 2018 by American Society of Clinical Oncology. Open access (pdf)

Safety of higher dosages of Viscum album L. in animals and humans - systematic review of immune changes and safety parameters. Kienle GS, Grugel R, Kiene H: BMC Complement Altern Med 2011, 11:72 http://www.biomedcentral.com/content/pdf/1472-6882-11-72.pdf

Viscum album L. extracts in breast and gynaecological cancers: a systematic review of clinical and preclinical research. Kienle GS, Glockmann A, Schink M, Kiene H: Journal of Experimental & Clinical Cancer Research: CR 2009, 28:79 http://www.biomedcentral.com/content/pdf/1756-9966-28-79.pdf

Complementary cancer therapy: a systematic review of prospective clinical trials on anthroposophic mistletoe extracts. Kienle GS, Kiene H: Eur J Med Res 2007, 12:103-119 http://www.daig-net.de/site-content/die-daig/fachorgan/2007-1/ejomr-2007_3-pdfs/S.103_Kienle.pdf

Influence of Viscum Album L (European Mistletoe) Extracts on Quality of Life in Cancer Patients: A Systematic Review of Controlled Clinical Studies. Kienle GS, Kiene H: Integr Cancer Ther 2010, 9:142-157 http://ict.sagepub.com/content/9/2/142.long

Mistletoe therapy in oncology (Review). Horneber MA, Bueschel G, Huber R, Linde K, Rostock M. Reprint of a Cochrane review, prepared and maintained by The Cochrane Collaboration and published in The Cochrane Library 2008, Issue 2. http://www.thecochranelibrary.com

Mistelihoito: Satunnaistetut kontrolloidut tutkimukset

Quality of life of patients with advanced pancreatic cancer during treatment with mistletoe: a randomized controlled trial. Tröger, W.; Galun, D.; Reif, M.; Schumann, A.; Stanković, N.; Milićević, M. 2014. Quality of life of patients with advanced pancreatic cancer during treatment with mistletoe: a randomized controlled trial. Dtsch Ärztebl Int 111(29–30): 493–502. doi:10.3238/arztebl.2014.0493. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4150026/; http://www.aerzteblatt.de/pdf.asp?id=161151

Additional therapy with a mistletoe product during adjuvant chemotherapy of breast cancer patients improves quality of life. Tröger, W.; Ždrale, Z.; Tišma, N.; Matijašević, M. 2014. Additional Therapy with a Mistletoe Product during Adjuvant Chemotherapy of Breast Cancer Patients Improves Quality of Life: An Open Randomized Clinical Pilot Trial. Evid Based Complement Alternat Med 2014: 430518. doi:10.1155/2014/430518. https://www.hindawi.com/journals/ecam/2014/430518/

Viscum [L.] extract therapy in patients with locally advanced or metastatic pancreatic cancer: a randomised clinical trial on overall survival. Tröger, W.; Galun, D.; Reif, M.; Schumann, A.; Stanković, N.; Milićević, M. 2013. Viscum album [L.] extract therapy in patients with locally advanced or metastatic pancreatic cancer: a randomized clinical trial on overall survival. Eur. J. Cancer 49(18): 3788–3797. https://www.ncbi.nlm.nih.gov/pubmed/23890767; http://www.ejcancer.com/article/S0959-8049%2813%2900550-9/pdf

NCCAM/NCI Phase 1 Study of Mistletoe Extract and Gemcitabine in Patients with Advanced Solid Tumors. Mansky PJ, Wallerstedt DB, Sannes TS, Stagl J, Johnson LL, Blackman MR, Grem JL, Swain SM, Monahan BP: Evidence-Based Complementary and Alternative Medicine 2013, 2013: 964592 http://www.hindawi.com/journals/ecam/2013/964592/

Five-year follow-up of patients with early stage breast cancer after a randomized study comparing additional treatment with a mistletoe extract to chemotherapy alone. Tröger, W.; Ždrale, Z.; Stanković, N.; Matijašević, M. 2012. Fiveyear follow-up of patients with early stage breast cancer after a randomized study comparing additional treatment with viscum album (L.) extract to chemotherapy alone. Breast Cancer (Auckl) 6: 173–180. doi:10.4137/BCBCR.S10558. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493140/

Quality of life is improved in breast cancer patients by Standardised Mistletoe Extract PS76A2 during chemotherapy and follow-up: a randomised, placebo-controlled, double-blind, multicentre clinical trial. Semiglasov VF, Stepula VV, Dudov A, Schnitker J, Mengs U: Anticancer Res 2006, 26:1519-1530 http://ar.iiarjournals.org/content/26/2B/1519.full.pdf

Impact of complementary mistletoe extract treatment on quality of life in breast, ovarian and non-small cell lung cancer patients. A prospective randomized controlled clinical trial. Piao BK, Wang YX, Xie GR, Mansmann U, Matthes H, Beuth J, Lin HS: Anticancer Res 2004, 24:303-309 http://ar.iiarjournals.org/content/24/1/303.full.pdf

Mistelihoito: Ei-satunnaistetut, kontrolloidut tutkimukset ja kohorttitutkimukset

Intravenous Mistletoe Treatment in Integrative Cancer Care: A Qualitative Study Exploring the Procedures, Concepts, and Observations of Expert Doctors. Kienle GS, Mussler M, Dieter Fuchs and Kiene H. Evidence-Based Complementary and Alternative Medicine, Volume 2016, Article ID 4628287, http://dx.doi.org/10.1155/2016/4628287

Targeting inflammation in cancer-related-fatigue: a rationale for mistletoe therapy as supportive care in colorectal cancer patients. Bock, P.R.; Hanisch, J.; Matthes, H.; Zänker, K.S. 2014. Targeting inflammation in cancer-related-fatigue: a rationale for mistletoe therapy as supportive care in colorectal cancer patients. Inflamm Allergy Drug Targets 13(2): 105–111. https://www.ncbi.nlm.nih.gov/pubmed/24766319 

Intratumoral mistletoe therapy in patients with unresectable pancreas carcinoma: a retrospective analysis.Schad, F.; Axtner, J.; Buchwald, D.; Happe, A.; Popp, S.; Kröz, M.; Matthes, H. 2013. Intratumoral Mistletoe (Viscum album L) Therapy in Patients with Unresectable Pancreas Carcinoma: A Retrospective Analysis. Integr Cancer Ther 13(4): 332–340. https://www.ncbi.nlm.nih.gov/pubmed/24363283

Quality of life in breast cancer patients during chemotherapy and concurrent therapy with a mistletoe extract. Eisenbraun, J.; Scheer, R.; Kröz, M.; Schad, F.; Huber, R. 2011. Quality of life in breast cancer patients during chemotherapy and concurrent therapy with a mistletoe extract. Phytomedicine 18(2–3): 151–157. doi:10.1016/j.phymed.2010.06.013. https://www.ncbi.nlm.nih.gov/pubmed/20724129

Anthroposophic supportive treatment in children with medullo-blastoma receiving first-line therapy. Seifert, G.; Rutkowski, S.; Jesse, P.; Madeleyn, R.; Reif, M.; Henze, G.; Längler, A. 2011. Anthroposophic supportive treatment in children with medulloblastoma receiving first-line therapy. J. Pediatr. Hematol. Oncol. 33(3): e105–108. doi:10.1097/ MPH.0b013e31820946d3. https://www.ncbi.nlm.nih.gov/pubmed/21368673

Mistelihoito: havaintotutkimukset, tapausselostukset ja tapaussarjatutkimukset

Durable Clinical Remission of a Skull Metastasis Under Intralesional Viscum album Extract Therapy - A Case Report. Werthmann PG, Huber R, Kienle GS. Head & Neck 2018;00:1–5. Read more

A 21-year course of Merkel cell carcinoma with adjuvant Viscum album extract treatment: A case report. Werthmann PG, Kindermann L, Kienle GS. Complementary Therapies in Medicine. Volume 38, June 2018, Pages 58-60. Read more

Complete Remission and Long-term Survival of a Patient with a Diffuse Large B-cell Lymphoma Under Viscum album Extracts After Resistance to R-CHOP: A Case Report. Gutsch J, Werthmann PG, Rosenwald A, Kienle GS: Anticancer Research. September 2018 vol. 38 no. 9 5363-5369. doi: 10.21873/anticanres.12865 Open access

Long-term tumor-free survival in a metastatic pancreatic carcinoma patient with FOLFIRINOX/Mitomycin, high-dose, fever inducing Viscum album extracts and subsequent R0 resection: A case report. Werthmann PG, Inter P, Welsch T, Sturm A-K, Grützmann R, Debus M u. a. . Medicine. Dezember 2018;97(49):e13243. Full text

Intralesional and subcutaneous application of Viscum album L. (European mistletoe) extract in cervical carcinoma in situ. A CARE compliant case report.Reynel MB, Villegas Y, Kiene H, Werthmann PG, Kienle GS: Medicine: November 2018 - Volume 97 - Issue 48 - p e13420, doi: 10.1097/MD.0000000000013420. Full text

Tumour response following high-dose intratumoural application of Viscum album on a patient with adenoid cystic carcinoma. Werthmann, P.G.; Helling, D.; Heusser, P.; Kienle, G.S. 2014. Tumour response following high-dose intratumoural application of Viscum album on a patient with adenoid cystic carcinoma. BMJ Case Rep 2014; pii:bcr2013203180. doi:10.1136/bcr-2013-203180. http://casereports.bmj.com/content/2014/bcr-2013-203180.abstract

Durable response of cutaneous squamous cell carcinoma following high-dose peri-lesional injections of Viscum album extracts. Werthmann, P.G.; Sträter, G.; Friesland, H.; Kienle, G.S. 2013. Durable response of cutaneous squamous cell carcinoma following high-dose peri-lesional injections of Viscum album extracts – a case report. Phytomedicine 20(3–4): 324–327. doi:10.1016/j.phymed.2012.11.001. https://www.ncbi.nlm.nih.gov/pubmed/23394841

Mistelihoito: yhteenveto tilanne 3/2017